“It's painful for me to watch someone who isn't funny. It's horrifying to sit in the back and watch some guy who just totally sucks.”
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The misconception is that standup comics are always on. I don't know any really funny comics that are annoying and constantly trying to be funny all the time.
The audience changes every night. You're the same person. You have to speak your mind and do the stuff that you think is funny and makes you laugh.
Your body's really only meant to compete at the highest levels of combat sports for a few years.
I wouldn't totally rule out doing Letterman or the Tonight Show if I had a set that I just happened to write that I thought was funny but was still appropriate for network censors. But I'm not going to go out of my way.