“All the suffering and joy we experience depend on conditions.”
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And as long as you're subject to birth and death, you'll never attain enlightenment.
The ignorant mind, with its infinite afflictions, passions, and evils, is rooted in the three poisons. Greed, anger, and delusion.
If you use your mind to study reality, you won't understand either your mind or reality. If you study reality without using your mind, you'll understand both.
Not engaging in ignorance is wisdom.